The course covers the structural and functional characterisation of the major macromolecules of the cell with special emphasis on DNA and proteins (the Nucleic acids, DNA replication and transcription, and protein synthesis linked in a historical perspective). The classification, properties and application of enzymes and coenzymes, the effects of pH and temperature on enzyme-catalysed reactions are some of the highlights of this course. Regulation of enzyme activity by organics including recent developments in the tools and techniques of DNA and protein isolation and characterization will be demonstrated during practical sessions.