The course introduces students to enzyme specificity, stereo- and geometric factors that contribute to enzyme catalysis; general acid-base catalysis and covalent catalysis. Catalysis by coenzymes; pyridoxal phosphate, thiamine pyrophosphate, ATP, coenzyme A, NAD(P)+ , FAD/FMN are also treated.  These will be illustrated using the structure and mechanism of action of selected enzymes such as dehydrogenases, proteases, ribonuclease, lysozyme, and glycolytic enzymes such as phosphofructokinase (PFK).