This course presents the theory and methodology of organic synthesis.  The initial focus will center on the methodology necessary to synthesize complex organic molecules.  It will include an in-depth look at functional group transformations, carbon-carbon bond forming reactions, ring-forming reactions, aromatic chemistry and heterocyclic chemistry. It will also discuss the use of retrosynthetic analysis and the “disconnection approach” to logical guide total synthesis.  Finally, a number of literature syntheses will be used to examine the strategies involved in formulating a total synthesis emphasizing the compatibility of functional groups, sequence of reactions, use of protecting groups and the impact of stereochemistry.