Organisation and Planning: Protocol, patient selection, response. Justification of  method for randomisation: Uncontrolled trials, blind trials, Placebo’s, ethical issues. Survival function, hazard functions, cumulative hazard function, censoring. Kaplan-Meier survival curve, parametric models. Dynamics of isolated and interacting populations, cobwebbing. The basic laws of genetics. Mutation. Inherited defects in man.