This course is concerned with the study of biochemical changes in human body under pathological conditions. It emphasises the biochemical basis of disorders such as acid / base imbalance and the abnormal metabolism of carbohydrates, lipids, proteins, amino acids, nucleic acids, bile pigments, vitamins and hormones. Inherited disorders in metabolism, the role of enzyme levels in prognosis of biochemical dysfunctions are major component of the course. Quality Assurance in clinical laboratory, organ (Liver, kidney, heart, pancreas, GIT etc) tests, the meaning and interpretation of findings both traditional and functional will be discussed.