This course provides students with insight into the chemistry of pharmaceuticals with in–depth explanation on the molecular mechanisms of drug action. It is also aimed at helping students to refine their skills in writing organic reaction mechanism and develop a better understanding of structure/ reactivity relationship found in organic molecules. The course will cover basic introductory materials which and govern drugs (discovery optimization and design) and their action, dermatologic and cosmetics applications.
The course presents a broad survey of the phenomena isomerism, optical isomerism due to independent asymmetric carbon atoms, and stereoisomerism of compounds containing identical asymmetric carbons atoms. Topics to be discussed will include asymmetry of inorganic elements, alkenes, alkylidene, cycloalkanes, spirans and biphenyl; dissymmetry of restricted rotation and molecular overcrowding; enantiomers; symmetry element; racemic modification; epimerization; and resolution. Other relevant topics such as absolute and configuration; Rectus and Sinister system; stereochemistry of simple derivatives of cyclopropane, cyclobutane, cyclopentane, and decalins; and acyclic and cyclic system will also be discussed.
The course will discuss the failures of classical mechanics and will introduce the students to photoelectric effect, Compton effect, wave-particle duality of light, and Heisenberg’s Uncertainty Principle as well as the Bohr atom. The course will consider the postulates and general principles of quantum mechanics, three-dimensional systems, perturbation theory, and the particle in a box. Other topics will include the hydrogen atom, multi-electron atom, molecular spectroscopies and their selection rules. Prerequisite: students are expected to take Level 100 and 200 Mathematics courses in Further Calculus and Differential Equations.
This course has a link to CHE 104 (Introductory Practical Organic Chemistry) and will enable students to be able to undertake a simple project work in organic chemistry using basic laboratory techniques such as separation, purification and identification of compounds of binary and tertiary mixtures. The course will also offer students the techniques involved in spectroscopic methods for the identification and total synthesis of simple organic compounds.
The course offers a more advanced on kinetic concepts related to chemical processes with an emphasis on how mechanistic proposals arise from measurements. Topics to be discussed will include: molecularity of elementary reactions, determination of reaction order, experimental rate law, steady-state approximation, pseudo first order reactions, complex reactions (parallel, series, consecutive and reversible reactions), collision theory, and transition state theory. It will also introduced students to reactor designs (batch and continuous reactors), and heterogeneous catalysis (acid-base catalysis and enzymatic catalysis). Prerequisite: CHE 203
This course offers a more advanced discussion on the application of energy in daily situations. Topics to be discussed include ideal and real gases, first law of thermodynamics,
reversible and irreversible processes, isothermal and adiabatic expansion, work, entropy and the second law of thermodynamics, Carnot cycle and heat engines, entropy changes
in both physical and chemical processes, Maxwell’s relations, chemical potential and fugacity. Prerequisite: CHE 203
This course focuses on the fundamental principles of analytical methods in Chemistry. Topics to be discussed will concepts based on analytical sampling, experimental uncertainty, statistical data analysis, glassware and instrument calibrations, volumetric analysis, solvent extraction, gravimetry, titrimetry (acid–base, complexometric, precipitation and redox titrations), and Beer’s law and its related chemical and instrumental deviations. Students will also be introduced to the principles of optical instrumentation, atomic spectroscopy and chromatographic methods.
The course introduces students to qualitative organic analysis, and physical and chemical properties of organic compounds. Experiment will be carried out on
structural elucidation of aldehydes, ketones, carboxylic acids and their derivatives.
This course focuses on providing fundamental understanding of the various solution properties and explanation of their relevant physico-chemical phenomena, electrolytes,
solution thermodynamics and transport properties, as well as, structure and properties of fluids. Topics to be discussed in this course will include colligative properties, thermodynamics
of electrolytes, solution transport and kinetics properties, ionic equilibria, analysis of kinetic results and reactions approaching equilibrium, and intermolecular forces within liquids and solids.
This course Topics to be discussed in this course will include the following: (a) structure, physical and chemical properties, and synthesis carboxylic acids and amines,
and their derivatives; (b) stereochemistry, and chirality of compound containing one and two asymmetric centres; (c) carbohydrates (monosaccharides - basic ideas of nomenclature),
and simple chemistry of sugars; and (d) proteins (classification, amino acids, peptides), determination of protein structure, nucleic acids, and nucleotides and synthetic polymers.